منابع مشابه
Skp2, the FoxO1 hunter.
Skp2 is an oncoprotein that mediates the degradation of several negative regulators of the cell cycle to promote cell proliferation. A recent report by Huang and colleagues reveals that Skp2 directs the ubiquitylation and subsequent degradation of FoxO1, a member of the FoxO family of transcription factors. Since FoxO proteins possess tumor suppressor functions, this new finding suggests a new ...
متن کاملSkp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis. Loss of function of these factors due to phosphorylation and proteasomal degradation has been implicated in cell transformation and malignancy. However, the ubiquitin ligase necessary for the ubiquitination of the FOXO factors and the re...
متن کاملSkp2
Polyubiquitination is a post-translational modification process, which modulates a myriad of biological processes. Its dysregulation is associated with the development of human cancer and many other diseases, implicating the potential of targeting the ubiquitination system as a therapeutic strategy. Skp2, as an F-box protein of SCF E3 ubiquitin ligase, directly interacts with Skp1 and indirectl...
متن کاملStudies of the flora and Hunter bacteria of Jordan
Jordan University of Science and Technology (Irbid, Jordan), Research Triangle Institute (North Carolina, USA) and Virgina Polytechnic Institute and State University (Virgina, USA) were granted an R21 planning grant funded by FDA, USA through an International Cooperative Biodiversity Group (ICBG) program to study the Hashemite Kingdom of Jordan’s flora and soil microorganism as a source of new ...
متن کاملThe Story of William Hunter
recognition of the value of the microscope). However, these advances only really bore fruit in the 1914 British Pharmacopoeia where, for instance, ash values and the histology of powders were conspicuous for the first time. (That interest in powder histology developed so late despite the early recognition of nefarious practices by the drug grinders is a subject deserving full study.) The 1914 B...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2005
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2005.02.014